N,n&#39;-diacyl-tetrahydro-1,3,5-oxadiazines



Patented Jan. 3, 1950 UNITED STATES PATENT GFFICE Madison" Bunt, Claymont, and Harris Walton Bradley, Wilmington, Del., assignors to4 E.' I; du R011#- de Nemours & Company, Wilmington,l Dele. c connotation. of Delaware N12-Drawing. li'llililication` December 14,A 1946, Serial No. 716,438.

4i (Cl. 2601.-244) This invention relates to new organic comis formed. When the latter isY treated with pyri- IiO-uiids useful as intermediates forthefpreparadine, a di-quaternary-oompound is obtained 'havtion of' Water-reinellericyA agents. ing the structure IU is. known in theL art. to.. react longechain B Q 0 N VCH ,V N Q1 aliphatic acyl amides with dry formaldehyde 6 (triox-ymethylene), in the presence of hydrogen chloride to produce an intermediate methyl "Bi chloride compound (EPCI-HCD, which when treated. with. pyridine forms. e. wat-ensemble ad dition compound which isk useful as a water 10 repellency agent (U` S.. P. 2.29.6-,412-i.

It is also Qld t0 treat. a. iongechain aliphatic acylamide, for instance. steaigamide, with dry formaldehyde (parafoljmaldehyde) in an alkaline medium to produce an intermediate meth- 1.5 ylol compound (R-C-HzOH). When this compound is. treated. with peridinemrdroehloride it produces a Water-solublev addition compound useful as a Water-repellency agent. 13. 2,146,- 392). According to the. pateliteesv the; product -20 ismonomerio both before and. eiter reaction-with pyridineehydrochloride. In the case oi s tearanie ide, the intermediate Prod-uct is. Stearohydroxymethylamide (otherwiseknown es nietiiylol ste.-v aram-ide) and corresponds to the formula CiiHasr-CONHl-.CHZQI-I.

We have Ilow found that, alQilGhain. 3.1iphatic acyl; amide. is reacted with formaldehyde in the presence of rilliie..` sulionifo acid, more especially an, aromatic sulfQlle aCiti the 30 reaction takes a Still. difiereni; CQllrSQf im@ BIJCYQHC llxteitohltftgrewticiliagoinlo stlllifag :3111* intermediate compciindis obtanedcontanirig two ments amare einem sa eine tief' me Deduction Of novel intermediates m We i 9- 'Q 35 repellencyagentsby reactineanacyl, amidefhay- R-QQ-NTQH an aliphatic chain 0.1' atleast 8 carbon atoms,

H, with dry formaldehydein the presence ot a cet- R/ C lt m alyt quantity of an` aromatic sulfonic, acid., Reaction is conveniently brought. about by whereinR and R.' are like or different. hydrQGaI-e 40 heating .a mixture of the.. acylamide 'and Dambon radmals earch* QQn-lmgm NW1 n1-ampi formaldehyde in the presence of a catalyt at least 3 carbon atome.. bei. my' be otfhelwls quantity of an aromatic sulfonic acid ata. temstraight-eiminedA ory branched. saturated or- 1111- peretureof about. 14o-15.0.o C. for about onechour. saturated, and may contain also, aromatic or The frml of 'the pr'odt mdifesftht, a Cycloaphat@ adical Ereferred form 45 minimum of 1.5 moles ofkformaldeliyde are, re- Of this inl/enum", E and Bf" al@ Straightchainf lquired i01- each moleV ofb acylamide y In praesaturated hydrocarbon radicalsv contaning 11 to tice; 'an xcs of pfa, formaldehyde. is` prefer- 29 Cabfmtomsably employed, say 2 moles (calculated as CHzO) If pms mtermedate is treated Wlth hydrogen for each mole of acylamlde. In some cases, it chlollde the Oxadlazme Img opens up and the 50 is advantageous to use about three moles of pocorfespondm'g bis'chloromethyl compound of the tential formaldehyde for eac-h mole of amide.

Reco- .onrene-ci f and being useful as a waier-.repelleney agent. It Will be noted that methyleneebisiacylamido.- methyl-pyridinium chloride), compOlmds; of. this type, have been prepared before by Rogers, U. S.` P. 2,386,140, but he found. it necessary to start. with a methylene-bis-acylamide and react the same. with paraformaldehrde and hydrogen chloride or with dichlor-dimethyl ether to produce an intermediate bis-chloiomethyl compound. Furthermore, in Rogers* process the reaction requires. a solvent, which entails. the use of. larger apparatus and thenecessity. of handling andA recovering the solvent; italso gives. the.. entire process. e, certain degree of fire. hazard. The novel intermediate products of. this invention, on the other hand, are of low melting point, and

formula' R CO N CH C! The amount of catalyst employed mayV vary between 0.5% and 10% based on the weight o1 H amide used. The reaction may be carried out B-O cali-omo; 55 at atmospheric pressure or in a closed vessel at pressures up to 1000 lbs. per square inch. The reaction occurs rather slowly below 140 C. and the reaction mixture has a tendency to become solid. The latter handicap may be avoided by carrying out the reaction in an inert solvent, such as toluene, in which case temperatures as W as 100 C. may be used. The time cycle, however, is materially increased at such lower temperatures, and the procedure is less advantageous than working without a solvent.

Without limiting our invention, the following example is given to illustrate our preferred mode of operation. Parts mentioned are by weight.

Example 1 A mixture of 28.3 parts of a commercial mixture of stearamde and palmitamide (substantially equimolecular) and 1.0 part of p-toluenesulfonlc acid monohydrate is heated to 140 C. To this mixture are added 6.0 parts of paraformaldehyde over a period of one hour. The mixture is stirred vigorously throughout this period and for minutes after addition is complete. The crude reaction product, which may contain up to 10% of methylene-diacylamides such as methylene-distearamide as impurities, melts at 52-55" C. The pure N,N'diacyltetrahydro-1,3,5oxadiazine can be obtained by crystallization of the crude product from acetone or methyl ethyl ketone. Analysis, calc. for Cs'zH'zzNzOa (based on an equimolecular mixture of stearic and palmitic acid derivatives): C, 75.00%; H, 12.16%; N, 4.73%. Found: C, 74.75%; H, 11.99%; N, 4.65%, A determination of active hydrogen by the Standard Zerevitinoi method showed essentially no active hydrogen.

Reaction of the above product with hydrogen chloride gives the corresponding methylene-bis- (acylamido-methyl chloride), and further treatment of the latter with pyridine gives the corresponding methylene-bis(acylamide-methyl pyridinium chloride) of high purity and exceptionally high quality as a water-repellent.

The process of preparing our novel intermediate may be combined with the process of converting it into a water-repellency agent in a single continuous process, without isolating any intermediate products. This is illustrated in the following example:

' Example 2 The procedure of Example 1 is followed up to and including the step of stirring vigorously for 15 minutes, following the addition of the paraformaldehyde. The molten mass is then cooled to 100 C. and hydrogen chloride is bubbled in for 1 hour, until a total of 4.2 parts of hydrogen chloride has been passed in. 8.5 parts of pyridine are then added slowly, with cooling and stirring, the temperature being held at 10C-120 C. during this period. The product is then poured into a container.

The quaternary derivative formed in the above reaction is isolated by crystallization of the crude product from methyl-ethyl ketone.. In order to remove the small amount of methylene-distearamide and methylene-dipalmitamide formed in the reaction, it is necessary to discard about the i from moist solvents.

iirst 2.5 parts of product which separate on crystallization. The yield of purifled product is 26.0 parts. The compound is a white crystalline solid melting at -90 C. as first isolated. On drying in a high vacuum the product is apparently dehydrated and then melts at 112114 C. The hydrate can be regenerated by recrystallization The product is soluble in Warm Water yielding a, foaming solution. Analysis calc. for C47Ha2N4O2Cla2H2O: N, 6.66%; Cl. 8.44%. Found: N, 6.70%; C1, 8.25%. (The calculatedv values are based on an equimolecular mixture of stearic and palmitic acid derivatives.)

In lieu of p-toluene-sulfonic acid, benzenesulfonic acid, chlorobenzene-sulfonic acid or any other convenient aromatic sulfonic acid of the benzene or naphthalene series may be employed. provided it is free of substituents (such as OH, NH2 or CONHz) which are reactive toward formaldehyde.

In lieu of the particular mixture of acylamides employed in this example, any other acylamide or mixture of acylamides of the group hereinabove discussed may be employed. As convenient, practical instances oi such amides may be mentioned: pelargonamide, undecylamide, lauramide, myristamide, palmitamide, stearamide, oleamide, arachidamide, p-dodecylbenzamide, p-octadecylcyclohexane carbonamide, 2 methylstearamide, and 2-ethy1 caprylamide.

We claim as our invention:

1. A compound of the general formula R'C0-1lr H. wherein R. and R stand for alkyl radicals having 8 to 30 carbon atoms. 2. The process of producing an intermediate for water-repellency agents, which comprises heating, at a temperature of about to 150 C., 1 mole of a fatty-acidamide having an alkyl chain of at least'8 carbon atoms with from 1.5 to 3 moles of dry formaldehyde and with from 0.5 to 10% by weight of an aryl sulfonic acid selected from the group consisting of benzene-sulfonic acid, p-toluene-sulfonic acid, chlorobenzenesulfonic acid and naphthalene sulfonic acid, whereby to produce the corresponding N,Ndi acyl-tetrahydro-1,3,5-oxadiazine.

3. The process of producing an intermediate for water-repellency agents, which comprises heating at a temperature of about 140 to 150 C. substantially 1 mole of a mixture of stearamide and palymitamide with substantially 2 moles of paraformaldehyde (calculated as CHzO) and with from 0.5 to 10%l by weight of p-toluenesulfonic acid, whereby to produce the corresponding N,N-diacyl derivative of terahydro1,3.5 oxadiazine.

4; A process as in claim 3, followed by recovery of said N,N-cliacyl-tetrahydro-1,3,5-oxadiazine by recrystallization of the crude mass in an inert organic solvent.

MADISON HUNT.

HARRIS WALTON BRADLEY.

No references cited. 

1. A COMPOUND OF THE GENERAL FORMULA 